Castro threw a seven-inning no-hitter on August 18, 2009 versus Dayton – the first in Fort Wayne franchise history.

Simon Castro went 10-6 with a 3.33 ERA across 28 games, including 27 starts with the Fort Wayne TinCaps. In 140.1 innings, he allowed 118 hits, walked 37 and struck out 157. He held the opposition to a .228 average. The opposition stole 14 bases off him in 22 attempts. He allowed nine homers, hit 10 batters, tossed 15 wild pitches, and induced three double play grounders. The opposition hit .263 off him in 118 at-bats with runners in scoring position. Castro led the Midwest League in strikeouts and was fifth in ERA. Castro was 10th in the entire minor leagues in strikeouts and eighth in strikeouts per nine innings pitched.

2008

Castro went 2-3 with a 3.99 ERA across 15 starts with the Eugene Emeralds. In 65.1 innings he allowed 54 hits, 29 walks and struck out 64. He allowed three homers and induced four double play grounders while holding the opposition to a .223 average.

2007

Castro went 2-6 with a 6.22 ERA over 14 games, including 12 starts, for the AZL Padres. In 50.2 innings he allowed 61 hits, walked 30 and struck out 55. He tied for the league lead in losses.

2006

The right-hander went 1-3 with a 4.63 ERA for the Dominican Summer League (DSL) Padres. In 46.2 innings, he allowed 40 hits, walked 21 and struck out 58. Castro did uncork nine wild pitches and twice tossed two in any game last year. He had a 1.89 ERA in July last year and a 9.00 mark in April and 5.48 ERA in August. Righties hit .208 off him in 2006.