Manuel Nuno hit .194 across 62 games with the DSL Padres. He went 39-for-201 with a team high 14 doubles, six homers, 39 runs scored and 42 RBI. He posted a .365 on-base percentage with a 47-to-76 walk-to-strikeout ratio while getting hit by 10 pitches. He was thrown out in his only stolen base attempt and committed 12 errors in the field. He hit .203 with runners in scoring position. Nuno grounded into three double plays. He led the team with five sacrifice flies.

2008

Nuno went 34-for-186 across 59 games for the DSL Padres. He hit .183 with eight doubles, five homers, 19 runs scored and 26 RBIs. He also drew 31 walks compared to 65 strikeouts.