Higelin went 0-0 with a 0.00 ERA over two games for the Eugene Emeralds. In two innings he allowed one hit and a walk while also hitting a batter.

Higelin went 0-3 with a 5.22 ERA over 41 games with the Lake Elsinore Storm. In 50 innings he allowed 61 hits and walked 22 while striking out 41. He allowed four homers, hit one batter, and tossed seven wild pitches while inducing six double play grounders. He saw the opposition steal five bases off him in nine attempts.

Higelin went 0-0 with a 0.00 ERA over four Storm playoff games. In three innings he allowed four hits, walked one and struck out two.

2006

Brandon Higelin was named to the Midwest League All-Star team in 2006, representing the Fort Wayne Wizards.

Higelin went 3-4 with a 2.28 ERA over 53 appearances for the Fort Wayne Wizards. In 67 innings he allowed 60 hits, walked 21 and struck out 62. The opposition hit .241 off him with four homers.

2005

He went 0-2 with a 5.00 ERA in 22 appearances for Eugene. In 27 innings, he gave up 40 hits and 11 walks while striking out 21.

Higelin was taken in the 28th round of the 2005 draft by the San Diego Padres out of Cal State Los Angeles.