"It's great that I could do it at home," Bonds said.
Barry Bonds is one of three players to have 700 or more homers, joining Babe Ruth and Hank Aaron in exclusive company.
It was over thirty years ago when Hank Aaron hit his 700th home run, back in July of 1973.
In the top of the third inning, Bonds launched a bomb off a Jake Peavy curveball on an 0-1 pitch. The shot went 392 feet into the opposite field, finally giving someone on that side of the field some love. It was his third homer off Peavy and 42nd of the year.
"You have to use your entire repertoire against Barry," said Peavy who took the loss.
Fireworks went off as Bonds rounded the bases and the Giants also unveiled enormous banners, one featuring Bonds 700 and another showing action shots of Ruth and Aaron as well as their home run totals.
"Hitting 700 homers is like a pitcher winning 400 games," manager Felipe Alou said.
For the Padres, who lost 4-1, it was a bitter pill to swallow.
"I hate to see it against us in an important game like this," said Padres manager Bruce Bochy.
Third baseman Sean Burroughs underwent successful surgery on his right knee Friday to repair a torn lateral meniscus and will sit out the remainder of the year.
The 24-year-old Burroughs, who set career highs this season with a .298 batting average, 156 hits and 76 runs, injured the knee sliding into second base during the Padres' 7-3 win over Los Angeles on Wednesday.
Burroughs was San Diego's first selection in the 1998 draft and made his major league debut in 2002. In 339 career games, he owns a .289 average with 10 home runs and 116 RBI.